Paul H. Krebsbach, DDS, PhD, is the Donald A. Kerr Collegiate Professor of Oral Pathology, Associate Professor of Dentistry and Associate Professor of Biomedical Engineering at the University of Michigan. He currently serves as the Associate Chair of the Department of Oral Medicine, Pathology and Oncology. Dr Krebsbach received his D.D.S. degree from the University of Minnesota in 1987 and his certificate in Periodontology and Ph.D. in Biomedical Sciences from the University of Connecticut in 1993. Prior to joining the faculty at the University of Michigan, he served as a Senior Staff Fellow for three years at the National Institutes of Health.

Dr. Krebsbach has served on several local and national committees including the AADR William J. Gies Award Committee, the AADR Hatton Award Committee, the Scientific Advisory Boards for the 7th and 8th International Conferences on the Chemistry and Biology of Mineralized Tissues, the American Association for the Advancement of Science Electorate Nominating Committee of the Section on Dentistry and Oral Health Sciences and the NIH Special Grants Study Section Panel. He reviews manuscripts for several journals and is on the editorial board of the International Journal of Oral and Maxillofacial Surgery. He currently serves the University of Michigan on the Center for Gene Therapy Executive Committee, the Rackham Graduate School Rackham Divisional Board and several Dental School committees including the Executive Committee. His research program focuses on the cell and molecular biology of mineralized tissues with an emphasis on gene therapy-directed osteogenesis and bone marrow stromal cell biology.

Education:
1982 - B.A., College of Saint Thomas, Saint Paul, MN, Biology
1987 - D.D.S., University of Minnesota, Minneapolis, MN, Dentistry
1993 - Ph.D., University of Connecticut, Farmington, CT, Oral Biology
1996 - Post-Doctorate, National Institute of Dental Research, Bethesda,MD, Molecular Biology

Academic Appointments:

1993-1996 - Senior Staff Fellow, National Institute of Dental Research, NIH, Bethesda, MD
1996-2001 - Assistant Professor, University of Michigan, School of Dentistry, Ann Arbor, MI
2001-Present - Associate Professor of Dentistry and Associate Professor of Biomedical Engineering, University of Michigan, Ann Arbor, MI

Honors, Awards and Public Service:

1984-1986 St. Paul District Dental Society George Monson Grant
1984-1985 Univ. of Minnesota Century Club Research Fellowship
1985-1986 NIH Summer Research Fellowship, Univ. of MN
1986-1987 UROP Junior Scientist Training Grant, Univ. of MN
1987-1988 NIH/Periodontal Pathobiology Training Grant
1988-1993 NIH/Dentist Scientist Award
1992 Young Investigator Award, American Society for Bone and Mineral Research
1995 Young Investigator Award, International Conference on the Chemistry and Biology of Mineralized Tissues.
1999-2004 NIH/NIDCR Independent Scientist Award
1999-present Editorial Board, International Journal of Oral and Maxillofacial Surgery
2001-2005 Member, NIH Study Section, NIDCR Special Grants Review Committee

Publications:

1. Jenkins, G.N., Krebsbach, P.H., Experimental Study of the Migration of Charcoal Particles in the Human Mouth. Arch. Oral Biol. 30: 697-699, 1985.
2. Ophaug, R.H., Jenkins, G.N., Singer, L., Krebsbach, P.H., Forms of Fluoride in Dental Plaque. Arch. Oral Biol. 32: 459-461, 1987.
3. Herzberg, M.C., Gong,K., MacFarlane, G.D., Erickson, P.R., Soberay, A.H., Krebsbach, P.H., Manjula, G., Schilling, K., Bowen,W.H. Phenotypic Characterization of Streptococcus sanguis Virulence Factors Associated with Bacterial Endocarditis. Infection and Immunity. 58: (2) 515-522, 1990.
4. Bogdanovic, Z., Bedalov, A., Krebsbach, P.H., Pavlin, D., Woody, C.O., Clark, S., Thomas, H., Rowe, D., Kream B.E. and Lichtler, A.C. Upsteam Regulatory Elements Necessary for Expression of the Rat COL1A1 Promoter in Transgenic Mice. J. Bone and Mineral Research. 9: (2) 285-292 1994.
5. Kream, B.E., Harrison, J.R., Krebsbach, P.H., Bogdanovic, Z., Bedalov, A., Pavlin, D., Woody, C.O., Clark, S., Rowe, D.W. and Lichtler, A.C. Regulation of Type I Collagen Gene Expression in Bone. Connective Tissue Res. 31: (4), 261-264. 1995.
6. Krebsbach, P.H., Harrison, J.R., Woody, C.O., Lichtler, A.C., Rowe, D.W., Kream, B.E. Transgenic Expression of COL1A1 Fusion Genes in Bone: Differential Utilization of Promoter Elements in vivo and in Cultured Cells. Molecular and Cellular Biology, 13: (9) 5168-5174, 1993.
7. Savagner, P., Krebsbach, P.H., Hatano, O., Miyashita, T., and Yamada, Y. Collagen II Promoter and Enhancer Elements Interact Synergistically through Sp1 and Distinct Nuclear Factors, DNA and Cell Biology 14: (6) 501-510, 1995.
8. Krebsbach, P.H., Lee, S.K., Matsuki, Y., and Yamada, Y. Full-length sequence, localization, and chromosomal mapping of ameloblastin: a novel tooth-specific gene. J. Biol. Chem., 271: (8), 4431-4436, 1996.
9. Krebsbach, P.H., Nakata, K., Bernier,S., Hatano, O. and Yamada, Y. Identification of a minimum enhancer sequence for the type II collagen gene reveals several core sequence motifs in common with the link protein gene. J. Biol. Chem., 271: (8), 4298-4305, 1996.
10. Lee, S.K, Krebsbach, P.H., Matsuki, Y., and Yamada, Y. Developmental Expression of Ameloblastin in Rat incisors and Human Tooth Germs. International Journal of Developmental Biology. 40: 1141-115, 1996.
11. Nakata, K., Miyamoto, S., Bernier, S., Tanaka, M., Utani, A., Krebsbach, P., Rhodes, C., Yamada, Y. The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription. Ann N Y Acad Sci 785:307-8, 1996.
12. MacDougall, M., DuPont, B.B., Simmons, D., Reus, B., Krebsbach, P.H., Karrman, C, Holmgren, G., Leach, R.J., and Forsman, K. Ameloblastin gene (AMBN) Maps within the Critical Autosomal Dominant Amelogenesis Imperfecta Region at Chromosome 4q21 Genomics 41: 115-118, 1997.
13. Krebsbach, P.H., Kuznetsov, S., Rowe, D.W., and Gehron Robey, P. Bone Formation in vivo by Transplanted Marrow Stromal Fibroblasts: Comparison of Mouse and Human Models. Transplantation 63: 1059-1069, 1997.
14. Kuznetsov, S, Krebsbach, P.H., Satomura, K., and Gehron Robey, P. Single-Colony Derived Strains of Human Stromal Fibroblasts Form Bone After Transplantation in vivo. J. Bone Miner. Res. 12: 1335-1347, 1997.
15. Paine, M.L., Krebsbach, P.H., Yamada, Y., Deutsch, D., Snead, M.L. Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix . J. Dent. Res. 77(3): 496-502, 1998.
16. Harrison, J.R., Hartigan, L., Budz, P.L., Krebsbach, P.H., Woody, C., Rowe, D.W., Lichtler, A.C. Kream, B.E. Interleukin-1a Represses Activity of COL1A1-CAT Fusion Genes in Transgenic Mouse Calvariae in vitro and in vivo. J. Bone Mineral Res. 13: 1076-1083, 1998.
17. Nanci, A., Zalzal, S., Lavoie, P., Kunikata, M., Chen, W.-Y., Krebsbach, P.H., Yamada, Y., Hammarstrom, L., Simmer, J.P., Fincham, A.G., Snead, M.L., Smith, C.E.Comparative immunochemical analyses of the developmental expression oand distribution of ameloblastin and amelogenin in rat incisors. J. Histochem. Cytochem, 46:911-934, 1998.
18. Begue-Kirn, C., Krebsbach, P.H., Bartlett, J.D., Butler, W.T. Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific proteins that are distinctively expressed during murine dental differentiation. European Journal of Oral Sciences106:963-970, 1998.
19. Simmons, D., Gu, T.T., Krebsbach, P.H., Yamada, Y., and MacDougall. M. Identification and Characterization of a cDNA for Mouse Ameloblastin. Connect Tiss Res 39:307-316, 1998.
20. Krebsbach, P.H., Mankani, M.H., Satomura, K., Kuznetsov, S.A., and Gehron Robey, P. Repair of Critical-Size Osseous Defects in Mice using Bone Marrow Stromal Cells. Transplantation, 66: 1272-1278, 1999.
21. Wang, D., Christensen, K., Krebsbach. P.H., Franceschi, R.T. Isolation and characterization of MC3T3-E1 prosteoblastic subclones with distinct in vitro and in vivo differentiation/mineralization potential. J. Bone Miner. Res. 14 (6) 893-90 1999.
22. Dhamija, S., Lui, Y., Yamada, Y., Snead, M.L., and Krebsbach, P.H., Cloning and Characterization of the Murine Ameloblastin Promoter. J Biol. Chem., 274 (29) 20738-20743 1999.
23. Krebsbach, P.H., Kuznetsov, S.A., Bianco, P., Gerhon Robey, P. Bone Marrow Stromal Cells: Characterization and Clinical Application, Critical Reviews in Oral Medicine and Biology, 10 (2): 165-181, 1999.
24. Feinberg, S.E., Hollister, S.J., Halloran, J.W., Chu, T.M., and Krebsbach, P.H. A Tissue Engineering Approach to Site-Specific Reconstruction of Skeletal Structures of the Maxillofacial Region part 1. Shanghai Journal of Stomatology. Vol.9:1 36-40. 2000.
25. Feinberg, SE, Hollister, SJ, Halloran, JW, Chu, TM, Krebsbach, P.H.: A Tissue Engineering Approach to Site-Specific Reconstruction of Skeletal Structures of the Maxillofacial Region: Part 2”, Shanghai Journal of Stomatology, 9:88-93, 2000.
26. Satomura, K., Krebsbach, P.H., Bianco, P., and Gehron Robey, P. Osteogenic Imprinting Upstream of Marrow Stromal Cell Differentiation. J Cell Biochem 78:391-403 2000.
27. Franceschi R.T., Wang, D., Krebsbach, P.H., Rutherford, R.B. Gene Therapy of Bone formation: In vitro Osteogenic Activity of an Adenovirus Expressing BMP-7., J Cell Biochem 78:3 476-486, 2000.
28. MacDougall, M., Simmons, D., Gu, T. T., Forsman-Semb, K., Mardh, C. K., Mesbah, M., Forest, N., Krebsbach, P. H., Yamada, Y., Berdal, A. Cloning, Characterization and Immunolocalization of Human Ameloblastin, Eur J Oral Sci. 108(4):303-310, 2000.
29. Feinberg, S.E., Hollister, S.J., Halloran, J.W., Chu, T.M., and Krebsbach, P.H. Role of Biomimetics in Reconstruction of the Temporomandibular Joint. Oral and Maxillofacial Clinics of North America. Vol 12:1, 149-160. 2000.
31. Krebsbach, P.H., Gu, K., Franceschi, R.T., and Rutherford, R.B. Gene Therapy Directed Osteogenesis: BMP-7 Transduced Gingival Fibroblasts Form Bone In Vivo. Human Gene Therapy 11:8 1201-1210, 2000.
32. Mankani, M.H., Krebsbach, P.H., Satomura, K., Kuznetsov, S.A., Hoyt, R., Gehron Robey, P. Pedicled Bone Flap Formation by Transplanted Bone Marrow Stromal Cells. Archives of Surgery, 136:263-270, 2001.
33. Feinberg, S.E., Hollister, S.J., Chu, T.M., Halloran, J.W. and Krebsbach, P.H. Image-Based Biomimetic Approach to Reconstruction of the Temporomandibular Joint. Cells Tissues Organs 169:309-321, 2001
34. Dhamija, S. and Krebsbach, P.H, Role of Cbfa1 in Ameloblastin Gene Transcription,
J Biol Chem 276 (37) 35159-35164, 2001.
35. Krebsbach, P.H. and Robey P.G. Dental and Skeletal Stem Cells: Potential Cellular Therapeutics for Craniofacial Regeneration Journal Of Dental Education Vol 66:6, 766-773, 2002.
36. Rutherford, R.B., Moalli, M., Franceschi, R.T., Wang, D., Gu, K., and Krebsbach, P.H. Bone Morphogenetic Protein-Transduced Human fibroblasts Convert to Osteoblasts and Form Bone In Vivo. Tissue Engineering 8(3) 441-452, 2002.
37. Kohn, D.E., Sarmadi, M., Helman, J., and Krebsbach, P.H. Effects of pH on Human Bone Marrow Stromal Cells in Culture: Implications for Tissue Engineering of Bone. J Biomed Mat Res 60:2 292-299, 2002.
38. D. Kaigler, P.H. Krebsbach, P.J. Polverini, D J. Mooney, Role of VEGF in Bone Marrow Stromal Cell Modulation of Endothelial Cells, Tissue Engineering 9 (1): 95-103 2003.
39. Rutherford R.B., Nussenbaum B., and Krebsbach P.H. BMP-7 ex vivo Gene Therapy, Drug News & Perspectives, 16(1) 5-10, 2003.
40. Taboas, J.M., Maddox, R.D., Krebsbach, P.H., and Hollister, S.J. Indirect Solid Free Form Fabrication of Local and Global Porous, Biomimetic and Composite 3D Polymer-ceramic Scaffolds. Biomaterials 24: 181-194, 2003.
41. Rutherford, R.B., Gu, K., Racenis, P, and Krebsbach, P.H. Early Events in the in vitro Conversion of BMP Transduced Fibroblasts to Chondroblasts, Connective Tissue Research, 44:117-1232, 2003.
42. Yang S, Wei D, Wang D, Phimphilai M, Krebsbach PH and Franceschi RT, In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation. J Bone Miner Res 18:705-715, 2003.
43. Krebsbach P.H., Zhang, K., Malik, A., and Kurachi, K. Bone Marrow-Derived Stromal Cells as a Genetic Platform for Systemic Delivery of Therapeutic Proteins in vivo: Human Factor IX Model., J Gene Medicine 5:11-17, 2003.
44. Schneider A, Taboas JM, McCauley LK. and Krebsbach PH. Skeletal Homeostasis in Tissue Engineered Bone, Journal of Orthopedic Research, in press, 2003.
45. Paine, M.L., Krebsbach, P.H., Snead, M.L, A Transgenic Animal Model for Amelogenesis Imperfecta Related to Ameloblastin Over-expression, in press, J. of Biol. Chem. 2003
46. Nussenbaum, B., Rutherford, R.B., Teknos, T. N., Dornfeld, K. J. and Krebsbach, P. H., Ex vivo Gene Therapy for Skeletal Regeneration in Cranial Defects Compromised by Preoperative Radiation. In Press, Human Gene Therapy. 2003

Book Chapters and Proceedings:

1. Tsumaki, N., Lui, Y., Yamada, Y., Krebsbach, P.H., Enhancer Analysis of the a1(II) and a2(XI) Collagen Genes in Transfected Chondrocytes and Transgenic Mice. Methods in Molecular Biology, vol 139: Extracellular Matrix Protocols, ed. C. Streuli and M. Grant , Humana Press Inc., Totowa, NJ., 187-195. 2000
2. Krebsbach, P.H., and Polverini, P.J., Dental Manifestations of Disorders of Bone and Mineral Metabolism, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, American Society for Bone and Mineral Research. Lippincott Williams and Wilkins , Philadelphia, 1999.
3. Optimal Design and Fabrication of Tissue Engineering Scaffolds S.J. Hollister, J.M. Taboas, R.D. Maddox, T.M. Chu, P.H. Krebsbach, and S.E. Feinberg, Proceedings of International Symposium on Computational Methods in Biomechanics and Biomedical Engineering, In Press, 2003
4. Nussenbaum, B. and Krebsbach, P.H. Practical Matters in the Application of Tissue Engineered Products for Skeletal Regeneration in the Head and Neck Region, Proceedings of the American Association of Orthopedic Surgeons, in press, 2003
5. Krebsbach, P.H., and Polverini, P.J., Dental Manifestations of Disorders of Bone and Mineral Metabolism, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, American Society for Bone and Mineral Research. In press 2003.

Invited Editorials:

1. Krebsbach, P.H., Yamada, Y. Role of the First Intron in the Regulation of the COL 1A1 Gene Matrix Biol 15(2):64- 70, 1996
2. Krebsbach P.H., Ignelzi, M.A. Jr. Failure to Attract and Retain Clinician/Scientist Faculty Puts Profession at Risk. J. Dent. Res. 78:1576-1578, 1999.